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Low Electric Charge / No 2° Structure
Low charge effects (ionic bonds and hydrogen bonds) to the target proteins
cause minimum changes of structure and function of the target proteins
POP(2B8) tag does not change the pI of target protein while other traditional tags cause undesirable pI change
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The unique Proline-rich sequence (4 out of 9 amino acids) does not induce secondary / tertiary structure
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